10 New Alternatives to Opioids For Pain

W-18 (4-Nitrophenylethyl)

When it comes to dangerous legal opioids, W-18 without a doubt has to be at the top of the list, as it is said to be 10,000 times more potent than that of morphine. You will find that most alternatives and synthetic opioids on this list are considered safe, but that cannot be said about W-18.

The only reason that W-18 in on this list is so that people can understand just how dangerous it is. This synthetic drug is so dangerous that it was linked to nearly 300 deaths during the year 2015 in Canada.

BDPC (Bromadol)

BDPC first came on the market back in the late seventies and it is a powerful narcotic analgesic. In fact, some people online have referred to this drug as a frat boy’s heroin.

However, there have been other users that have stated that they’ve experienced serious aid when dealing with opioid withdrawal symptoms while taking this drug.

There have even been reports stating that this drug provides relief without getting them high. Whatever this situation is, recent studies have shown that his drug is 10,000 times more powerful than that of morphine.


O-Desmethyl-Tramadol is a synthetic painkiller that is extremely similar to other designer drugs. Over the years research and studies show that this power synthetic medication is a lot less addictive than other legal opioids.


Kratom is without a doubt one of the safest, if not the safest options on this list. It is an all-natural pain reliever that attacks the kappa-opioid receptors just like opioids do.

However, it should be noted that this powerful herb should be in a class of its own, as it doesn’t come along with the nasty respiratory side effects that most opioids do.

In fact, the side effects of Kratom can be described as minimal at best.

Kratom was first used as a folk medicine thousands of years ago, and more and more individuals are turning to this powerful miracle herb for assistance with pain relief.

white vein kratom


Herkinorin is a lot less potent than a lot of the other legal opioids on this list, but it is still said to be 100 times more powerful than that of morphine. With that being said, Herkinorin has become widely known for its unique properties, as it is said to not have any tolerance.


U-47700 is a legal opiate and it is often time referred to as pink. This opiate should be considered just as highly dangerous as the first one that was mentioned in this list. This opiate is imported for China and it is usually injected into the veins like morphine and heroin.

With that being said, this drug has widely been praised because it doesn’t really seem to come along with any nasty side effects or withdrawal symptoms.

However, it should be noted that some users have reported minor motor coordination impairment when taking this powerful agent.



When it comes to Hydromorphone a lot of individuals often times get confused and this is completely understandable, as Hydromorphone is also known as dihydromorphone. However, it is still marketed as Dilaudid, which can be confusing when it comes to trying to keep up with all the names.

Hydromorphone is considered to be much more powerful than oxycodone, while coming with a shelf life of three hours. In addition to this, this powerful drug can be administered orally or through the nose.

This medication is usually only prescribed when individuals are recovering from cancer or dealing with the post-op pain of broken bones.

Unfortunately, Hydromorphone does come along with some nasty side effects that are similar to that of morphine and heroin, which means that it can cause acute respiratory issues. Anyone concerned with these side effects, but still need the powerful benefits of this medication should consider trying something a little safer like Kratom.


Doctors have used corticosteroids for a wide number of years now to aid in treating neuropathic pain. Prednisone and Prednisolone are without a doubt two of the better known, as they can reduce inflammation, while helping manage the nasty symptoms cause by arthritis.

Corticosteroids have also been highly used to treat lower back pain, along with a variety of other pain conditions. Research and studies have shown that Corticosteroids have the ability to reverse pain, rather than just mask it like most opioids do.




Neurostimulators are really nothing new, but the use of them has changed. In fact, they are now being used to block pain signals. This is much different than most prescription medications, because they go straight to the source.

Most traditional pain medications just tend to relive pain, while posing serious side effects, but that is not the case with neurostimulation. Neurostimulation has the unique ability to target the source of the pain and eliminate anything from headaches to old sports related injuries.


It should be stated that PZM21 is still in the researching stages. While scientists and researchers alike are still trying to discover it medicinal value, it has been stated that this powerful medication can aid anyone that is seeking long-lasting pain relief.

In fact, it has been stated this medication is far more effective than morphine.

Throughout these studies the addiction factor of this medication still has not yet been discovered. While it does activate the reward section of the brain, researchers still don’t know how addictive this medication is when compared to morphine.

However, the most fascinating thing about this medication is that is doesn’t appear that its use comes along with any side effects whatsoever.

Final Thoughts 

Any individual seeking the use of the above-mentioned herbs or synthetic drugs should carefully vet their choices before making a decision. Not only will this help you find the herb or drug to meet your very specific needs, but this could prevent you from suffering harsh side effects as well.

With that being said, anytime you are taking herbs or synthetic medications you need to make sure that you are using them with caution.

Only take the prescribed amounts and only take them for a short period of time.

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